Difficult processing with these data: separating stars and galaxy with StarXTerminator doesn’t work well here, too many artefacts. So all the stretching was done with the starfull images, with just a bit of star reduction on L, to preserve the many little mostly blue stars in the arms of NGC 300.

More details at Astrobin.

IAS – Internationale Amateursternwarte e.V.– Hakos Observatory, Namibia
IAS remote telescope “Dieter”

Lacerta 12″ Newton f/4, ASA DDM85XL-A, QHY268M, Baader LRGB Ha 6.5 nm filters
Guiding with OAG and Lodestar X2
196x L, 60x R, 60x G, 60x B 120s, 59x Ha 180s, mode 1, gain 56, offset 10, -5C, 20 flats, 30 darks, 50 bias
Total time: 55740s / 15h29
Data acquisition: IAS remote team / Martin Junius
Data calibration/integration: PixInsight WBPP
Image processing: PixInsight, BlurXTerminator, NoiseXTerminator, StarXTerminator, Lightroom

See here for a previous attempt at this galaxy.